Probiotics are defined as live microbial food ingredients that produce severalÂ beneficial effects to human health . The effects of probiotics may be classified in threeÂ modes of action. (i) Probiotics might be able to modulate the hostâ€™s defenses. (ii)Â Probiotics can also have a direct effect on other microorganisms, commensal and/orÂ pathogenic ones. (iii) Finally, probiotic effects may be based on actions affectingÂ microbial products like toxins, host products e.g. bile salts and food ingredients. All threeÂ modes of probiotic action are in all likelihood involved in infection defense, prevention ofÂ cancer and in stabilizing or reconstituting the physiological balance between the intestinalÂ microbiota and its host. Numerous bacteria in and on its external parts protect the humanÂ body from harmful threats. Several animal studies have shown that supplementation withÂ specific strains of lactic acid bacteria (probiotics) could prevent the establishment,Â growth, and metastasis of transplantable and chemically induced tumors. An inverseÂ relationship between the consumption of fermented dairy products, containing lactobacilliÂ or bifidobacteria (are the main probiotic groups) Pediococcus, Lactococcus, Bacillus,Â Shirota, Caseii, Lactis, Rhamnosus, Plantarum and yeasts and the incidence of colon,Â gastric cancer and breast cancer has also been reported in epidemiological and populationÂ based case-control studies. The effectiveness in the treatment of cancers is based on theÂ restoration of the sensitivity of transformed cells to apoptotic signals. The anticancerÂ activity through induction of apoptosis of cancer cells seems to be promising approach forÂ use of some probiotic strains as a support therapy or disease prevention. A wealth of dataÂ implicates that special receptors have essential roles in tumor development. A wealth ofÂ evidence emerging from laboratory studies indicates anticancer activity of probiotics.