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Frequency of Pre-neoplastic Lesions and Gastric Cancer Among 11543 Patients from a Pathology Clinical Center between 2012 and 2016 in Iran

Abstract

This study was aimed to determine the frequency of atrophic gastritis (AG), intestinal metaplasia (IM), dysplasia, H. pylori infection and gastric cancer in pathologic reports of upper gastrointestinal biopsy samples in Mashhad, Iran. This retrospective epidemiological study was conducted in referral gastrointestinal laboratory of Mashhad in Iran between March 2012-2017. Biopsy reports of 11543 patients who underwent upper esophagogastroduodenoscopy was assessed for demographic information, AG, IM, H. pylori and cancer prevalence. The mean age of patients was 48.52 ± 17 and 52.7% of them were female. 49.8% of the patients were infected to H. pylori. Frequency of IM was 15.9% and it was significantly correlated with age, gender and H. pylori infection (P=0.0001). Frequency of AG among subjects was 2.7% which has significant correlation between gender, H. pylori infection, age and AG (P=0.0001). Only 0.4% of the patients had dysplasia. Dysplasia was associated with age, gender and H. pylori infection too (P= 0.0001, 0.001, 0.0001 respectively). The prevalence of carcinoma among our patients was 5.6% while 72% of the cancer patients were men. Furthermore, a significant correlation between age and carcinoma was observed. Frequency of carcinoma in H. Pylori was higher than negative individuals. Intestinal type gastric cancer (1.2%) was accounted for most of the gastric adenocarcinoma cases, followed by diffuse type (0.8%) and mixed type (0.2%).  Our results suggest that identification of high-risk patients should be included in a gastric cancer early detection program.

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How to Cite

Izanloo, A., Gholipour, A., Behrooznia, Z., Shariat Razavi, S. A., Ahmadi, M., Ebrahimi, S. A., Zargaran, B., Moghaddari, S., Ghandehari, M., Torabian, F., Rahimi Kakhki, R., Hamidi, F., Vosooghinia, S., Sharif, M., Jafarzadeh, N., Delavari Lotfabad, S., Poorali, S., Ghazaghi, A., Ghaffarzadehgan, K., Sima, H. R., Saber Afsharian, M., Goshayeshi, L., Ganji, A., Esmaeil Zadeh, A., Farzanehfar, M. R., & Ghaderi, P. (2021). Frequency of Pre-neoplastic Lesions and Gastric Cancer Among 11543 Patients from a Pathology Clinical Center between 2012 and 2016 in Iran. The Cancer Press Journal, 7(1), 7–13. https://doi.org/10.15562/tcp.87

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Azra Izanloo
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Ahmad Gholipour
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Zahra Behrooznia
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Seyed Ali Shariat Razavi
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Mokhtar Ahmadi
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